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WHAT IS MESTEROLONE (PROVIRON)? from freemexy's blog


Mesterolone (Proviron dosage) is the brand name for the oral androgen Mesterolone (1-methyldihydrotestosterone) from Schering-Plough (now Bayer). Similar to dihydrotestosterone, Mesterolone is a strong androgen with only a weak level of anabolic activity. Because it is similar to dihydrotestosterone, Mesterolone is rapidly reduced to inactive diol metabolites in muscle tissue with a higher concentration of 3-hydroxysteroid dehydrogenase. In fact, due to its extremely high affinity for plasma binding proteins such as SHBG, Mesterolone can actually enhance its steroid activity by replacing it with a free unbound state. Among athletes, Mesterolone is mainly used to increase androgen levels during thrift or preparation for competition, and as an antiestrogens due to its ability to antagonize aromatase.
Product History: According to company records, Schering-Plough developed Mesterolone in 1934. As an anabolic steroid, Mesterolone is ancient. It is the first clinical practice drug to treat "hormone-related diseases." Therefore, Mesterolone was developed at about the same time as methyltestosterone (1935) and testosterone propionate (1937), both of which are very old agents. Mesterolone has the efficacy and safety of clinical records in the flood season and is still widely used in clinical care today. Commonly used in men for the treatment of decreased physical and mental abilities caused by age and low androgen levels, low libido caused by insufficient androgen levels, hypogonadism (men before and after the spring period) and infertility (Mesterolone can improve the quality and quantity of sperm in specific situations). Mesterolone may be controversial as a fertility adjuvant, and anabolic/androgenic steroids are generally associated with infertility. This is also one of the misunderstandings of athletes on testosterone. Because of its androgenic nature, it is able to minimize the inhibition of gonadotropins in normal therapeutic doses, rather than because it increases the production of pro-chimogenin. Because it does not inhibit gonadotropins, the drug can supplement the androgens necessary for sperm production. It is well known that androgens have a direct stimulating effect on sperm production and also affect sperm transport and maturation by reacting epididymis, tubular structures and seminal vesicles. Therefore, these hormones are not all inhibitory. Mesterolone appears to have a unique positive impact on certain male fertility because its potential stimulating effect on sperm count and quality is not offset by gonadotropin inhibition. Mesterolone is widely produced and sold by Bayer (formerly Lingya) and has a presence in more than 30 countries around the world. Although Bayer has other agents in other markets, such as mestoranum and provironum, the most common trade name is proviron. In addition, other vendors have sold Mesterolone in the past few years, with brand names including: Pluriviron (Asche, Germany), Vistimon (jenepharm, Germany), and Restore (Brown & Burke, India). Even though Mesterolone's history of use is safe and effective, the FDA has never approved its entry into the US market. Today, Mesterolone can still be seen in the country. Bayer is still its main global supplier, but in rare cases it should still be able to see other brand names.
Structural features: Mesterolone (Proviron) is a modified form of dihydrotestosterone. The difference is that a methyl group is added at the carbon 1, which helps protect the hormone from liver damage during oral administration. The same structural modifications are also used for oral metoprolol tablets. The alkylation reaction at a specific position slows the metabolism of the steroid during the first passage through the liver, although it is far less pronounced than the c-17 alpha alkylated steroid. The overall bioavailability of Mesterolone remains much lower than that of c-17 alpha alkylated oral steroids, but Mesterolone is sufficiently resistant to achieve therapeutically beneficial blood levels. Mesterolone also has a strong binding affinity for sex hormone binding globulin and can be used to replace other steroids that bind weaker to SHBG. Side effects (estrogen): Mesterolone is not aromatized by the body and no estrogen is detected. Therefore, when using Mesterolone, the sterile line uses antiestrogens. Because Mesterolone does not cause gynecomastia, water retention or other estrogen-related side effects in men. It is believed that Mesterolone can be used as an anti-aromatase in the body to prevent or slow the conversion of steroids to estrogen. The effect is a bit similar to Ruining, but not so deep. The antiestrogenic properties of Mesterolone are not unique and many other steroids show similar activity. For example, dihydrotestosterone and tacroles are successfully used to treat male breast development and breast cancer due to strong androgenic and potential anti-estrogen. It has been suggested that noxan can be used to reduce aromatase activity, since noxe is more resistant to estrogen conversion (the most active part of the aromatics is the liver). The anti-estrogenity of all of these compounds may be due to their competition with other substrates for binding to aromatase. Because aromatase binds to steroids but does not alter it, it is temporarily blocked from interacting with other hormones.

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