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After a week of site visits, educational exchange and joint discussions, both sides are pleased to announce the establishment of an Overseas Study Centre at Adelaide International School’s Rundle Mall campus.Hangzhou School

Established in 2017, HYFLS is a new primary and junior middle school that fits within the respected Zhejiang Yuying Education Group and has 36 classes sharing a 3.8-hectare campus in the picturesque Donghai-Xianhu town, Hangzhou. The dual language school (Chinese & English) promotes a mixed educational approach rooted both in the Chinese traditional culture and the essence of western civilization.

By adding to its educational partnerships with other prominent schools throughout Asia, Adelaide International School is helping lead the way in trans-national cooperation between students, teachers and administrators; which in-turn adds to the unique international culture at Adelaide International School.

This agreement will allow students from both schools the opportunity to become exposed internationalism and set them on their pathway to global citizenship.
In an international competition for the ‘Teda High School in Tianjin, China’, organised by the city of Tianjin, schneider+schumacher have been awarded first prize. Their winning scheme proposes a complete – rather than partial – reconstruction of the school, originally built in the early school in Tianjin

This is the second success in China for schneider+schumacher, who run a main office in Frankfurt as well as offices in Tianjin, China and Vienna, Austria. Their other competition-winning proposal for the Civic Center in Hangzhou is about to start on site.

The site is centrally located in the city, in Tianjin’s ‘Teda Economic Development Zone’ located in the Binhai District. The current school has already established an excellent reputation and tellingly bears the name ‘Teda No. 1 School’.

The brief called for two different approaches. The core concept was to replace just some of the existing buildings with new structures, and to revitalise the remaining buildings. In the other concept, the architects were asked to ignore the existing constraints and consider the consequences of a erecting a totally new building.

schneider+schumacher’s design concept unites both these approaches by creating a coherent programme for phasing the construction work. The idea won unanimous approval from both the jury and the local politicians and convinced them to rebuild not just a few of the buildings, but the entire school.

The design comprises a single five-storey building of about 63,000 square metres, with a 180-metre long hallway – the school’s ‘backbone’ – acting as a central element linking all the other key areas. This backbone, aside from its role as circulation space, offers a pleasant, informal area where students will be able to meet and talk – a feature that traditional Chinese schools lack. On upper levels, connecting bridges meander through the red walls of the staircase, alluding to ‘Liu Shang Qu Shui‘, a traditional Chinese story about the collective creation, exchange, and transmission of knowledge.

The long hallway links together classrooms for a total of 2,700 students, the school cafeteria, the library, an auditorium for 600 people, and the sports hall. In keeping with the surrounding urban texture, these elements are clearly expressed as individual volumes. The elevation’s strict vertical and horizontal glass elements and stone-cladding sets the school visually apart from more typical Chinese school buildings, and the design aims to safeguard the school’s excellent reputation as well as provide a stimulating learning environment for students and teachers.
But when Wycombe Abbey, a girls' boarding school in Buckinghamshire, opens its doors in China in September, it will be not be launching a replica.
Wycombe Abbey International in Changzhou near Shanghai will be co-educational, and will teach a hybrid of the Chinese and English curriculums within an English-style boarding school environment.Tianjin international school
Alongside international GCSEs and A-levels, pupils will follow a Chinese curriculum in mathematics. And it won't be serving international students or UK families in China. Around 90% of the students will be local Chinese.We're catering to the insatiable demand in China for an English-medium education," said Wycombe Abbey's headmistress Rhiannon Wilkinson, who has also taught in Hong Kong and Brunei.
"But we are also responding to a need for an English-style education system and Chinese methods," she said.
"They don't want to be westernised but they want to apply to western universities."International schools were once a virtual foreign enclave within the host country, a preserve of internationally-mobile expatriate families working for multinational companies.
Now more local families are using international schools, where they study A-levels and International Baccalaureates from the UK and Advanced Placement programmes from the US, as a springboard to getting places in UK and US universities.
Some parents also want their children to rub shoulders with an international elite and build contacts for a future career.
More stories from the BBC's Knowledge economy series looking at education from a global perspective and how to get in touch
Another motivation is to escape the relentless drudgery and ferocious competition of a local school system based on rote learning and geared only towards exams.
"Families are worried about the pressure of the system on their children," said Ms Wilkinson.
There are now about 8,000 international schools around the world, teaching 4.26 million students, according to research by the International School Consultancy.From less than a dozen such schools in each country a decade or so ago, Thailand now has over 172 international curriculum schools, half of them following England's national curriculum.
Malaysia has 142, Japan 233, and Singapore - which makes it difficult for foreigners to enrol in local schools - around 63. Myanmar could also become a hotspot - Dulwich College will open there next year.
Hong Kong which had 92 such schools in 2000 now has 171.
Demand, particularly from local wealthy families is such that virtually all the leading international schools in Hong Kong have waiting lists, says ISC director Richard Gaskell, who is based in Bangkok.
Only South Korea has seen a retraction, with some international schools struggling to fill places.
But the big story is China. From a dozen schools 15 years ago, China has some 530 English-medium international schools, catering for 326,000 students.
moved abroad to Shanghai, China at the end of August 2018. The decision to work and live abroad in Shanghai was motivated by a job opportunity with The Walt Disney Company. I started working for the company in May 2014 as a performer through the college program at Walt Disney World in Orlando. I was intrigued to see how a company as big as Disney functioned in China compared to in the United States. Moving to Shanghai
I work as an English teacher for young children through Disney’s extracurricular English program known in China as Disney English. In 2017, China’s extracurricular education market exceeded $4 billion. Many Chinese parents are eager to enroll their children in an extracurricular program to give them a head start in school. Disney English has created their program as a standout among the many other English learning programs throughout China. Shanghai itself is an incredible city. There is a fascinating contrast throughout the city in almost every area. Take, for example, the food.
Within the same block, you will likely find carts selling cooked chicken feet, a common street food, and McDonald’s selling some of the exact burgers as in the US. You see the same contrast on the roads, which will be swept by hand with brooms made of bamboo branches, as Teslas and Rolls Royces drive by. It is a unique opportunity to live somewhere growing at a rate as fast as Shanghai, and I’m glad I made the decision to take on the challenge. While many cultural aspects in China including the language and food are still foreign to me, both experiences of working for Disney and living abroad have helped me appreciate how universal many of the classic Disney lessons are. Disney characters and their stories are beloved by the Chinese the same way they are by Americans.
For the past two years, Wu Dongmei’s 14-year-old son has been attending a private school in Shanghai that offers an international program that prepares students for higher education abroad. All had proceeded smoothly — until recently, she said.Shanghai private school

On Oct. 19, the Shanghai Municipal Education Commission summoned the principals of 21 local private schools to explain draft regulations that would restrict international programs in Grades 1 through 9, the years of compulsory education in China. The commission accused schools that had replaced the officially mandated curriculum, which includes classes in political ideology, of “infringing on China’s education sovereignty.”

The commission said that under the proposed regulations the authorities would no longer approve the establishment of any new private schools with “foreign influence” and would “bar foreign investment in private schools.” School curriculums would be monitored to ensure that they “uphold national sovereignty and ideology.” Private schools could not be named after foreigners.The rules would not apply to international schools set up primarily to educate foreign students.

A woman who answered the telephone at the commission’s office this week said that it was unclear when the new regulations, if approved, might take effect, but that any information would be posted on the commission’s website. The woman declined to give her name.
Now Ms. Wu is worried that the programs her son, who is in the ninth grade, is enrolled in might be replaced.

“Parents have been talking about the regulations, and some are even prepared to send their kids to schools overseas if there are major changes,” she said in an interview. She asked that her son’s school not be identified, out of concern that it might cause problems for him.
Jiang Xueqin, a researcher in Beijing for the Harvard University Global Education Innovation Initiative, said the proposed Shanghai regulations reflected the Chinese government’s concerns about political orthodoxy.

“The government has maintained tight ideological control over the universities, and high schools are entirely focused on test preparation, but there has been room for innovation in the grades 1-to-9 system,” Mr. Jiang said. “As the Chinese economy slows and instability grows, the government wants to ensure maximum control in the classroom.”
According to the Ministry of Education, 256 private and 225 public schools in China provide international education programs for Chinese students who hope to continue their studies abroad. These typically offer English or other courses students would need to prepare for foreign universities, instead of courses equipping them to take the gaokao, the Chinese college entrance examination.

Many private schools also omit the ideological instruction on Marxism and patriotism that is compulsory in public schools.Ms. Wu wondered whether the government might also require such courses in private schools, which have a high degree of autonomy in devising curriculums and teaching methods. “I believe politics should be separated from school education, although I know in China it’s difficult,” she said.

Investment in private schools across China has surged in recent decades. Education Ministry data from 2015 showed that China had 10,735 private schools offering grades 1 through 9, with more than 12 million students. That is more than 8.5 percent of all the students in these grades, up from 2.9 percent in 2004.

Driving the trend are wealthy families willing to pay for what they see as a higher-quality education. Some real estate developers have promoted private schools as features to help sell apartments. Local government officials have accepted private schools as a way to provide more consumer choice as well as stimulate the local economy, despite concerns that they exacerbate social inequality.

“Because private schools offer more money and autonomy” to staff members, Mr. Jiang said, “they’ve been draining a lot of top talent from the public school system. So while private schools promise to shake up an overly bureaucratic school system in China, they do so at the expense of equity and social mobility.”
But since President Xi Jinping came to power in 2012, the private and international education sectors have come under greater government scrutiny. In November, the Standing Committee of the National People’s Congress adopted revisions to a law barring for-profit private schools from offering classes for grades 1 through 9. According to Zhu Zhiwen, a vice minister of education, none of China’s registered private schools are for-profit, and the law only affects those who want to turn their schools into profit-led establishments, the state news media reported.
This is not the first crackdown on Western values in Chinese education. At a forum last year on ideological work in universities, Yuan Guiren, then the education minister, warned “never let textbooks promoting Western values appear in our classes.” Later that year, the Communist Party’s propaganda department and the Ministry of Education pushed universities to revive Marxist education.
Regulatory confusion over cannabinoids (CBD) has opened up the space for alternatives, within which Gencor has released Levagen, a palmitoylethanolamide (PEA) ingredient touted as having anti-inflammatory and pain relief properties. The company also utilizes a novel delivery method coined LipiSperse that increases the bioavailability of its PEA ingredient and allows for applications such as shots and chews. “This opens up the market and allows consumers to be more familiar with PEA. It can add value to products within the sports nutrition space,” Mariko Hill, Product Development Executive at Gencor tells NutritionInsight, at Vitafoods, Geneva, earlier this month.Palmitoylethanolamide powder

PEA is produced in the body as a biological response and as a repair mechanism for inflammation. It is a simple fatty acid amide that is structurally related to the endogenous cannabinoid transmitter, anandamide (AEA). AEA is associated with regulating pain and the more AEA in the bloodstream, the less discomfort a person may feel. PEA has numerous clinical studies demonstrating its potential as an effective and safe anti-inflammatory, analgesic and tissue-protective nutrient.

CBD was early this year classified as an unauthorized novel food and regulatory limitations may curb NPD, especially in the pain relief relating to sports nutrition space, according to Hill. This is where Gencor’s Levagen PEA comes in as an alternative, which can eliminate regulatory hurdles, she says. “This leaves space for an alternative like PEA, more specifically our brand ingredient Levagen, which acts on those receptors that boost energy and have anti-inflammatory properties,” Hill notes.

However, this does not mean that PEA is just an alternative. In places where cannabinoids face no regulatory issues, PEA can be used in combination with CBD to boost health benefits. In places where CBD is allowed, PEA can work synergistically with it, as they target those same pathways,” Chase Shryoc, Gencor’s Vice President of Sales and Business Development, tells NutritionInsight.

“PEA is a fatty acid and an endogenous module, which can be found in every cell in the body. It is an endocannabinoid receptor agonist, which means that it works in the endocannabinoid system, similar to CBD. CBD binds directly to CB1 and CB2 receptor sites, while Levagen PEA indirectly activates those same receptors and has that same effect, but from a different direction,” Shyroc explains.

Hill adds that although PEA is an alternative, people should look at it as a completely different product to CBD. “It works synergistically because it is an endocannabinoid and is actually produced in the body endogenously as well. Supplementation can then offset that balance within the body and you can also use it in combination with CBD, but since CBD is still a novel food that may present challenges.”

Gencor is using a new delivery method called LipiSperse, that can boost Levagen’s properties. LipiSperse is a novel system tailored to increase the dispersion of crystalline lipophilic agents in aqueous environments. Cold water dispersible (CWD) powders have an equilibrium established between the LipiSperse on the powder surface and the LipiSperse in the solution, according to the company.

“So there is a Levagen standalone and one supported by LipiSperse, which we call Levagen+, a cold-water dispersible powder. This delivery technology increases the bioavailability and functionality of the ingredient. We also did a PEA study in which Levagen+ is showing 1,8 higher absorption to standalone PEA,” Hill notes. The new delivery method allows for a broader spectrum of applications for the ingredient.

Levagen for osteoarthritis
Adding to the list of benefits for the ingredient, a new study has found that Levagen may have a beneficial effect on knee osteoarthritis and support healthy aging. The study published in the Inflammopharmacology Journal, aimed to examine the safety, tolerability and efficacy of PEA when dosed at 300mg and 600mg per day on symptoms of knee osteoarthritis.

“Osteoarthritis is one of the most common joint related concerns caused by the breakdown of articular cartilage and remodeling of joint tissues driven by inflammatory mediators,” says R.V. Venkatesh, Managing Director at Gencor. “The results of this study demonstrated the effects of Levagen and its ability to not only reduce pain but its ability to reduce anxiety levels, according to the Depression Anxiety Stress Scales (DASS).”

The eight-week, double-blind randomized placebo-controlled study also concluded that Levagen may be a novel treatment for attenuating pain and reducing other associated symptoms of knee osteoarthritis at both 300mg and 600mg per day.

“PEA is unique due to its several fast-acting therapeutic effects,” notes Shryoc. “The study recipients reported a gradual reduction of WOMAC pain scores in just one week with further significant reductions at week 4 and 8. In addition to joint health, Levagen can also aid in restful sleep and recovery.”

According to the company, there are additional clinical studies taking place with Gencor’s Levagen which are expected to be released later this year. Gencor is also putting additional research into Levagen+.

Palmitoylethanolamide is a fatty acid amide that is naturally present in our bodies. It mainly functions as a very comprehensive anti-inflammatory and pain reducer. In terms of pain reduction, it works great for individuals with neuropathic pain and produces significant back pain relief and sciatic pain relief. This is due to the fact that palmitoylethanolamide produces something called the ‘Entourage Effect’ an effect which potentiates the effects of Anandamide and it is naturally present in our bodies. Anandamide plays a crucial role in inflammation and pain perception, and Palmitoylethanolamide prevents the breakdown of anandamide and works to enhance its effects in the body. This pathway is especially effective at decreasing neuropathic pain and thus palmitoylethanolamide is very popular with people looking for sciatic pain relief and back pain relief.Palmitoylethanolamide

Palmitoylethanolamide also works to decrease inflammation by interacting with an enzyme called cyclooxygenase 2 (COX-2). This enzyme produces inflammation and is the target of most NSAIDs like Ibuprofen. These NSAIDs decrease pain perception by blocking COX-2 activity, whereas palmitoylethanolamide decreases pain perception by preventing the production of proinflammatory compounds that are produced by COX-2, such as prostaglandins D2 and E2.

Another unique effect that palmitoylethanolamide has, is that it activates the PPAR-alpha receptor. This receptor a major mediator of inflammation and pain perception and its activation causes a decrease in inflammation and a subsequent drop in pain perception.

Altogether, palmitoylethanolamide is a great compound for neuropathic pain and is a fantastic choice for individuals looking for sciatic pain relief and back pain relief.

*Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Palmitoylethanolamide, also known as PEA, is a endogenous fatty acid amide that has been demonstrated to exert a great variety of biological functions related to pain. Additionally, it has been shown to have neuroprotective properties. Pain management support dates as far back as before 1980. The birth of the molecule was in 1957 and it was in that year that 5 researchers believed that PEA was a natural pain management supplement.
Compound 7P powder is one of Neurotrophic drug. Axon regeneration after injury in the central nervous system is hampered in part because if an age-dependent decline in the intrinsic axon growth potential, and one of the strategies to stimulate axon growth in injured neurons involves pharmacological manipulation of implicated signaling pathways. Here we report phenotypic cell-based screen of chemical libraries and structure-activity-guided optimization that resulted in the identification of compound 7p which promotes neurite outgrowth of cultured primary neurons derived from the hippocampus, cerebral cortex, and retina. In an animal model of optic nerve injury, compound 7p was shown to induce growth of GAP-43 positive axons, indicating that the in vitro neurite outgrowth activity of compound 7p translates into stimulation of axon regeneration in vivo. Further optimization of compound 7p and elucidation of the mechanisms by which it elicits axon regeneration in vivo will provide a rational basis for future efforts to enhance treatment strategies.
We are a professional supplier of API in China, our Compound 7P with high quality and reasonable price. We are focused on providing our customers with the best service. Our high purity active ingredients is tested by HPLC.Compound 7P

Compound 7p exhibited 100% inhibition of parasitemia on day 4 at multiple doses(100, 50, and 25 mg/kg) given for four consecutive days, but at 100 mg/kg, all mice survived and were cured, while at 50 mg/kg, three of five mice survived and two mice were cured, and at 25 mg/kg, none of the mice survived
Reminyl is an Alzheimer's treatment derived from the bulbs of the daffodil, Narcissus pseudonarcissus. It is believed that neurons producing the neurotransmitter acetylcholine degenerate in the brains of patients with Alzheimer's disease. This loss of acetylcholine has been correlated with decreased cognitive function (thinking, remembering and reasoning). Reminyl works to increase the concentration of acetylcholine by blocking the action of acetylcholinesterase, an enzyme that catalyzes the hydrolysis (break down) of acetylcholine.Galantamine Hydrobromide powder

An estimated four million Americans have Alzheimer's disease -- a progressive loss of cognitive function so severe that it interferes with an individual's ability to function. The number is expected to grow to 14 million by the middle of the next century. The disorder is the third-most expensive illness in the United States, behind only heart disease and cancer.

Reminyl was developed by the Janssen Research Foundation under a co-development and licensing agreement with the UK-based Shire Pharmaceuticals. The drug will be marketed by Janssen Pharmaceutica and Ortho-McNeil Pharmaceutical in the United States.

Clinical Results
In trials ranging from 12 to 26 weeks, the effectiveness of Reminyl was measured using two primary tools. Subjects' abilities in terms of memory, orientation, reasoning and language were assessed using the cognitive portion of the Alzheimer's Disease Assessment Scale (ADAS-cog). Across all trials, results demonstrated that more subjects taking Reminyl showed significant improvement in their cognitive performance than subjects taking placebo.

The second primary measure of effectiveness was the Clinician's Interview-Based Impression of Change plus Caregiver Information (CIBIC-plus), which provides an overall assessment of patient functioning - including behavior, organized thinking and activities of daily living (such as dressing, eating and managing family finances). The CIBIC-plus results from all trials also showed that the overall scores for subjects taking Reminyl were statistically superior to placebo.
The most frequent adverse events associated with the use of Reminyl can be minimized by following the recommended dosage and administration.

Because this list is not all-inclusive, please consult a physician to discuss any side effects and the individual appropriateness of the drug.

Mechanism of Action
Galantamine, a tertiary alkaloid, is a competitive and reversible inhibitor of acetylcholinesterase. While the precise mechanism of galantamine's action is unknown, it may exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by cholinesterase. If this mechanism is correct, galantamine's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. (from Reminyl Prescribing Information).

In a small pilot study consume who consumed a natural dietary supplement called nicotinomide riboside (NR) daily showed signs of mimicking caloric restriction, which in mice has been linked to health benefits.Nicotinamide Riboside Chloride powder

Caloric restriction is a starvation diet. When lower level organisms such as fruit flies, roundworms, rodents are raised on such a diet from birth, slashing of caloric intake by about a third has health benefits and, in some cases, extended lifespan. No humans have done that, it would be a human rights violation to wean a baby on a starvation diet, and claims about benefits in adults who took it up have too many confounders to be anything more than anecdotes.

In a small pilot study, 12 lean and healthy men and women ages 55 to 79 from the Boulder area were given a placebo for six weeks, then took a 500 mg twice-daily dose of nicotinamide riboside chloride (NIAGEN). Another 12 took nicotinamide riboside for the first six weeks, followed by placebo. The researchers took blood samples and other physiological measurements at the end of each treatment period. They found that the supplement slightly improved blood pressure and arterial health, particularly in those with mild hypertension but what they wanted to find was that 1,000 mg daily of nicotinamide riboside boosted levels of another compound called nicotinamide adenine dinucleotide (NAD+) by 60 percent. NAD+ is required for activation of enzymes called sirtuins, which is hypothesized to be involved in the beneficial effects of calorie restriction. It's involved in a host of metabolic actions throughout the body, and tends to decline with age.

Some suggest that as an evolutionary survival mechanism, the body conserves NAD+ when subjected to calorie restriction and that led to the idea of supplementing with so-called "NAD+-precursors" like nicotinamide riboside to promote healthier aging.

The pilot study also found that in 13 participants with elevated blood pressure or stage 1 hypertension (120-139/80-89 mmHg), systolic blood pressure was about 10 points lower after supplementation. A drop of that magnitude could translate to a 25 percent reduction in heart attack risk but this is a pilot study in healthy people, so it should only be considered a viable technique if a company is willing to enter it into clinical trials. Otherwise, it will remain just another supplement for people who want to believe.
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