After a week of site visits, educational exchange and joint discussions,
both sides are pleased to announce the establishment of an Overseas
Study Centre at Adelaide International School’s Rundle Mall campus.
Hangzhou School
Established in 2017, HYFLS is a new primary and junior middle school
that fits within the respected Zhejiang Yuying Education Group and has
36 classes sharing a 3.8-hectare campus in the picturesque
Donghai-Xianhu town, Hangzhou. The dual language school (Chinese &
English) promotes a mixed educational approach rooted both in the
Chinese traditional culture and the essence of western civilization.
By adding to its educational partnerships with other prominent
schools throughout Asia, Adelaide International School is helping lead
the way in trans-national cooperation between students, teachers and
administrators; which in-turn adds to the unique international culture
at Adelaide International School.
This agreement will allow students from both schools the opportunity
to become exposed internationalism and set them on their pathway to
global citizenship.
In an international competition for the ‘Teda High School in Tianjin,
China’, organised by the city of Tianjin, schneider+schumacher have been
awarded first prize. Their winning scheme proposes a complete – rather
than partial – reconstruction of the school, originally built in the
early 1980s.
international school in Tianjin
This is the second success in China for schneider+schumacher, who
run a main office in Frankfurt as well as offices in Tianjin, China and
Vienna, Austria. Their other competition-winning proposal for the Civic
Center in Hangzhou is about to start on site.
The site is centrally located in the city, in Tianjin’s ‘Teda
Economic Development Zone’ located in the Binhai District. The current
school has already established an excellent reputation and tellingly
bears the name ‘Teda No. 1 School’.
The brief called for two different approaches. The core concept was
to replace just some of the existing buildings with new structures, and
to revitalise the remaining buildings. In the other concept, the
architects were asked to ignore the existing constraints and consider
the consequences of a erecting a totally new building.
schneider+schumacher’s design concept unites both these approaches
by creating a coherent programme for phasing the construction work. The
idea won unanimous approval from both the jury and the local politicians
and convinced them to rebuild not just a few of the buildings, but the
entire school.
The design comprises a single five-storey building of about 63,000
square metres, with a 180-metre long hallway – the school’s ‘backbone’ –
acting as a central element linking all the other key areas. This
backbone, aside from its role as circulation space, offers a pleasant,
informal area where students will be able to meet and talk – a feature
that traditional Chinese schools lack. On upper levels, connecting
bridges meander through the red walls of the staircase, alluding to ‘Liu
Shang Qu Shui‘, a traditional Chinese story about the collective
creation, exchange, and transmission of knowledge.
The long hallway links together classrooms for a total of 2,700
students, the school cafeteria, the library, an auditorium for 600
people, and the sports hall. In keeping with the surrounding urban
texture, these elements are clearly expressed as individual volumes. The
elevation’s strict vertical and horizontal glass elements and
stone-cladding sets the school visually apart from more typical Chinese
school buildings, and the design aims to safeguard the school’s
excellent reputation as well as provide a stimulating learning
environment for students and teachers.
But when Wycombe Abbey, a girls' boarding school in Buckinghamshire,
opens its doors in China in September, it will be not be launching a
replica.
Wycombe Abbey International in Changzhou near Shanghai will be
co-educational, and will teach a hybrid of the Chinese and English
curriculums within an English-style boarding school environment.
Tianjin international school
Alongside international GCSEs and A-levels, pupils will follow a
Chinese curriculum in mathematics. And it won't be serving international
students or UK families in China. Around 90% of the students will be
local Chinese.We're catering to the insatiable demand in China for an
English-medium education," said Wycombe Abbey's headmistress Rhiannon
Wilkinson, who has also taught in Hong Kong and Brunei.
"But we are also responding to a need for an English-style education system and Chinese methods," she said.
"They don't want to be westernised but they want to apply to western
universities."International schools were once a virtual foreign enclave
within the host country, a preserve of internationally-mobile
expatriate families working for multinational companies.
Now more local families are using international schools, where they
study A-levels and International Baccalaureates from the UK and Advanced
Placement programmes from the US, as a springboard to getting places in
UK and US universities.
Some parents also want their children to rub shoulders with an international elite and build contacts for a future career.
More stories from the BBC's Knowledge economy series looking at education from a global perspective and how to get in touch
Another motivation is to escape the relentless drudgery and
ferocious competition of a local school system based on rote learning
and geared only towards exams.
"Families are worried about the pressure of the system on their children," said Ms Wilkinson.
There are now about 8,000 international schools around the world,
teaching 4.26 million students, according to research by the
International School Consultancy.From less than a dozen such schools in
each country a decade or so ago, Thailand now has over 172 international
curriculum schools, half of them following England's national
curriculum.
Malaysia has 142, Japan 233, and Singapore - which makes it
difficult for foreigners to enrol in local schools - around 63. Myanmar
could also become a hotspot - Dulwich College will open there next year.
Hong Kong which had 92 such schools in 2000 now has 171.
Demand, particularly from local wealthy families is such that
virtually all the leading international schools in Hong Kong have
waiting lists, says ISC director Richard Gaskell, who is based in
Bangkok.
Only South Korea has seen a retraction, with some international schools struggling to fill places.
But the big story is China. From a dozen schools 15 years ago, China
has some 530 English-medium international schools, catering for 326,000
students.
moved abroad to Shanghai, China at the end of August 2018. The decision
to work and live abroad in Shanghai was motivated by a job opportunity
with The Walt Disney Company. I started working for the company in May
2014 as a performer through the college program at Walt Disney World in
Orlando. I was intrigued to see how a company as big as Disney
functioned in China compared to in the United States.
Moving to Shanghai
I work as an English teacher for young children through Disney’s
extracurricular English program known in China as Disney English. In
2017, China’s extracurricular education market exceeded $4 billion. Many
Chinese parents are eager to enroll their children in an
extracurricular program to give them a head start in school. Disney
English has created their program as a standout among the many other
English learning programs throughout China. Shanghai itself is an
incredible city. There is a fascinating contrast throughout the city in
almost every area. Take, for example, the food.
Within the same block, you will likely find carts selling cooked
chicken feet, a common street food, and McDonald’s selling some of the
exact burgers as in the US. You see the same contrast on the roads,
which will be swept by hand with brooms made of bamboo branches, as
Teslas and Rolls Royces drive by. It is a unique opportunity to live
somewhere growing at a rate as fast as Shanghai, and I’m glad I made the
decision to take on the challenge. While many cultural aspects in China
including the language and food are still foreign to me, both
experiences of working for Disney and living abroad have helped me
appreciate how universal many of the classic Disney lessons are. Disney
characters and their stories are beloved by the Chinese the same way
they are by Americans.
For the past two years, Wu Dongmei’s 14-year-old son has been attending a
private school in Shanghai that offers an international program that
prepares students for higher education abroad. All had proceeded
smoothly — until recently, she said.
Shanghai private school
On Oct. 19, the Shanghai Municipal Education Commission summoned the
principals of 21 local private schools to explain draft regulations
that would restrict international programs in Grades 1 through 9, the
years of compulsory education in China. The commission accused schools
that had replaced the officially mandated curriculum, which includes
classes in political ideology, of “infringing on China’s education
sovereignty.”
The commission said that under the proposed regulations the
authorities would no longer approve the establishment of any new private
schools with “foreign influence” and would “bar foreign investment in
private schools.” School curriculums would be monitored to ensure that
they “uphold national sovereignty and ideology.” Private schools could
not be named after foreigners.The rules would not apply to international
schools set up primarily to educate foreign students.
A woman who answered the telephone at the commission’s office this
week said that it was unclear when the new regulations, if approved,
might take effect, but that any information would be posted on the
commission’s website. The woman declined to give her name.
Now Ms. Wu is worried that the programs her son, who is in the ninth grade, is enrolled in might be replaced.
“Parents have been talking about the regulations, and some are even
prepared to send their kids to schools overseas if there are major
changes,” she said in an interview. She asked that her son’s school not
be identified, out of concern that it might cause problems for him.
Jiang Xueqin, a researcher in Beijing for the Harvard University
Global Education Innovation Initiative, said the proposed Shanghai
regulations reflected the Chinese government’s concerns about political
orthodoxy.
“The government has maintained tight ideological control over the
universities, and high schools are entirely focused on test preparation,
but there has been room for innovation in the grades 1-to-9 system,”
Mr. Jiang said. “As the Chinese economy slows and instability grows, the
government wants to ensure maximum control in the classroom.”
According to the Ministry of Education, 256 private and 225 public
schools in China provide international education programs for Chinese
students who hope to continue their studies abroad. These typically
offer English or other courses students would need to prepare for
foreign universities, instead of courses equipping them to take the
gaokao, the Chinese college entrance examination.
Many private schools also omit the ideological instruction on
Marxism and patriotism that is compulsory in public schools.Ms. Wu
wondered whether the government might also require such courses in
private schools, which have a high degree of autonomy in devising
curriculums and teaching methods. “I believe politics should be
separated from school education, although I know in China it’s
difficult,” she said.
Investment in private schools across China has surged in recent
decades. Education Ministry data from 2015 showed that China had 10,735
private schools offering grades 1 through 9, with more than 12 million
students. That is more than 8.5 percent of all the students in these
grades, up from 2.9 percent in 2004.
Driving the trend are wealthy families willing to pay for what they
see as a higher-quality education. Some real estate developers have
promoted private schools as features to help sell apartments. Local
government officials have accepted private schools as a way to provide
more consumer choice as well as stimulate the local economy, despite
concerns that they exacerbate social inequality.
“Because private schools offer more money and autonomy” to staff
members, Mr. Jiang said, “they’ve been draining a lot of top talent from
the public school system. So while private schools promise to shake up
an overly bureaucratic school system in China, they do so at the expense
of equity and social mobility.”
But since President Xi Jinping came to power in 2012, the private
and international education sectors have come under greater government
scrutiny. In November, the Standing Committee of the National People’s
Congress adopted revisions to a law barring for-profit private schools
from offering classes for grades 1 through 9. According to Zhu Zhiwen, a
vice minister of education, none of China’s registered private schools
are for-profit, and the law only affects those who want to turn their
schools into profit-led establishments, the state news media reported.
This is not the first crackdown on Western values in Chinese
education. At a forum last year on ideological work in universities,
Yuan Guiren, then the education minister, warned “never let textbooks
promoting Western values appear in our classes.” Later that year, the
Communist Party’s propaganda department and the Ministry of Education
pushed universities to revive Marxist education.
Regulatory confusion over cannabinoids (CBD) has opened up the space for
alternatives, within which Gencor has released Levagen, a
palmitoylethanolamide (PEA) ingredient touted as having
anti-inflammatory and pain relief properties. The company also utilizes a
novel delivery method coined LipiSperse that increases the
bioavailability of its PEA ingredient and allows for applications such
as shots and chews. “This opens up the market and allows consumers to be
more familiar with PEA. It can add value to products within the sports
nutrition space,” Mariko Hill, Product Development Executive at Gencor
tells NutritionInsight, at Vitafoods, Geneva, earlier this month.
Palmitoylethanolamide powder
PEA is produced in the body as a biological response and as a repair
mechanism for inflammation. It is a simple fatty acid amide that is
structurally related to the endogenous cannabinoid transmitter,
anandamide (AEA). AEA is associated with regulating pain and the more
AEA in the bloodstream, the less discomfort a person may feel. PEA has
numerous clinical studies demonstrating its potential as an effective
and safe anti-inflammatory, analgesic and tissue-protective nutrient.
CBD was early this year classified as an unauthorized novel food and
regulatory limitations may curb NPD, especially in the pain relief
relating to sports nutrition space, according to Hill. This is where
Gencor’s Levagen PEA comes in as an alternative, which can eliminate
regulatory hurdles, she says. “This leaves space for an alternative like
PEA, more specifically our brand ingredient Levagen, which acts on
those receptors that boost energy and have anti-inflammatory
properties,” Hill notes.
However, this does not mean that PEA is just an alternative. In
places where cannabinoids face no regulatory issues, PEA can be used in
combination with CBD to boost health benefits. In places where CBD is
allowed, PEA can work synergistically with it, as they target those same
pathways,” Chase Shryoc, Gencor’s Vice President of Sales and Business
Development, tells NutritionInsight.
“PEA is a fatty acid and an endogenous module, which can be found in
every cell in the body. It is an endocannabinoid receptor agonist,
which means that it works in the endocannabinoid system, similar to CBD.
CBD binds directly to CB1 and CB2 receptor sites, while Levagen PEA
indirectly activates those same receptors and has that same effect, but
from a different direction,” Shyroc explains.
Hill adds that although PEA is an alternative, people should look at
it as a completely different product to CBD. “It works synergistically
because it is an endocannabinoid and is actually produced in the body
endogenously as well. Supplementation can then offset that balance
within the body and you can also use it in combination with CBD, but
since CBD is still a novel food that may present challenges.”
Gencor is using a new delivery method called LipiSperse, that can
boost Levagen’s properties. LipiSperse is a novel system tailored to
increase the dispersion of crystalline lipophilic agents in aqueous
environments. Cold water dispersible (CWD) powders have an equilibrium
established between the LipiSperse on the powder surface and the
LipiSperse in the solution, according to the company.
“So there is a Levagen standalone and one supported by LipiSperse,
which we call Levagen+, a cold-water dispersible powder. This delivery
technology increases the bioavailability and functionality of the
ingredient. We also did a PEA study in which Levagen+ is showing 1,8
higher absorption to standalone PEA,” Hill notes. The new delivery
method allows for a broader spectrum of applications for the ingredient.
Levagen for osteoarthritis
Adding to the list of benefits for the ingredient, a new study has
found that Levagen may have a beneficial effect on knee osteoarthritis
and support healthy aging. The study published in the
Inflammopharmacology Journal, aimed to examine the safety, tolerability
and efficacy of PEA when dosed at 300mg and 600mg per day on symptoms of
knee osteoarthritis.
“Osteoarthritis is one of the most common joint related concerns
caused by the breakdown of articular cartilage and remodeling of joint
tissues driven by inflammatory mediators,” says R.V. Venkatesh, Managing
Director at Gencor. “The results of this study demonstrated the effects
of Levagen and its ability to not only reduce pain but its ability to
reduce anxiety levels, according to the Depression Anxiety Stress Scales
(DASS).”
The eight-week, double-blind randomized placebo-controlled study
also concluded that Levagen may be a novel treatment for attenuating
pain and reducing other associated symptoms of knee osteoarthritis at
both 300mg and 600mg per day.
“PEA is unique due to its several fast-acting therapeutic effects,”
notes Shryoc. “The study recipients reported a gradual reduction of
WOMAC pain scores in just one week with further significant reductions
at week 4 and 8. In addition to joint health, Levagen can also aid in
restful sleep and recovery.”
According to the company, there are additional clinical studies
taking place with Gencor’s Levagen which are expected to be released
later this year. Gencor is also putting additional research into
Levagen+.
Palmitoylethanolamide is a fatty acid amide that is naturally
present in our bodies. It mainly functions as a very comprehensive
anti-inflammatory and pain reducer. In terms of pain reduction, it works
great for individuals with neuropathic pain and produces significant
back pain relief and sciatic pain relief. This is due to the fact that
palmitoylethanolamide produces something called the ‘Entourage Effect’
an effect which potentiates the effects of Anandamide and it is
naturally present in our bodies. Anandamide plays a crucial role in
inflammation and pain perception, and Palmitoylethanolamide prevents the
breakdown of anandamide and works to enhance its effects in the body.
This pathway is especially effective at decreasing neuropathic pain and
thus palmitoylethanolamide is very popular with people looking for
sciatic pain relief and back pain relief.
Palmitoylethanolamide
Palmitoylethanolamide also works to decrease inflammation by
interacting with an enzyme called cyclooxygenase 2 (COX-2). This enzyme
produces inflammation and is the target of most NSAIDs like Ibuprofen.
These NSAIDs decrease pain perception by blocking COX-2 activity,
whereas palmitoylethanolamide decreases pain perception by preventing
the production of proinflammatory compounds that are produced by COX-2,
such as prostaglandins D2 and E2.
Another unique effect that palmitoylethanolamide has, is that it
activates the PPAR-alpha receptor. This receptor a major mediator of
inflammation and pain perception and its activation causes a decrease in
inflammation and a subsequent drop in pain perception.
Altogether, palmitoylethanolamide is a great compound for
neuropathic pain and is a fantastic choice for individuals looking for
sciatic pain relief and back pain relief.
*Attention: These statements have not been evaluated by the Food and
Drug Administration. This product is not intended to diagnose, treat,
cure or prevent any disease.
Palmitoylethanolamide, also known as PEA, is a endogenous fatty acid
amide that has been demonstrated to exert a great variety of biological
functions related to pain. Additionally, it has been shown to have
neuroprotective properties. Pain management support dates as far back as
before 1980. The birth of the molecule was in 1957 and it was in that
year that 5 researchers believed that PEA was a natural pain management
supplement.
Compound 7P powder is one of Neurotrophic drug. Axon regeneration after
injury in the central nervous system is hampered in part because if an
age-dependent decline in the intrinsic axon growth potential, and one of
the strategies to stimulate axon growth in injured neurons involves
pharmacological manipulation of implicated signaling pathways. Here we
report phenotypic cell-based screen of chemical libraries and
structure-activity-guided optimization that resulted in the
identification of compound 7p which promotes neurite outgrowth of
cultured primary neurons derived from the hippocampus, cerebral cortex,
and retina. In an animal model of optic nerve injury, compound 7p was
shown to induce growth of GAP-43 positive axons, indicating that the in
vitro neurite outgrowth activity of compound 7p translates into
stimulation of axon regeneration in vivo. Further optimization of
compound 7p and elucidation of the mechanisms by which it elicits axon
regeneration in vivo will provide a rational basis for future efforts to
enhance treatment strategies.
We are a professional supplier of API in China, our Compound 7P with
high quality and reasonable price. We are focused on providing our
customers with the best service. Our high purity active ingredients is
tested by HPLC.
Compound 7P
Compound 7p exhibited 100% inhibition of parasitemia on day 4 at
multiple doses(100, 50, and 25 mg/kg) given for four consecutive days,
but at 100 mg/kg, all mice survived and were cured, while at 50 mg/kg,
three of five mice survived and two mice were cured, and at 25 mg/kg,
none of the mice survived
Reminyl is an Alzheimer's treatment derived from the bulbs of the
daffodil, Narcissus pseudonarcissus. It is believed that neurons
producing the neurotransmitter acetylcholine degenerate in the brains of
patients with Alzheimer's disease. This loss of acetylcholine has been
correlated with decreased cognitive function (thinking, remembering and
reasoning). Reminyl works to increase the concentration of acetylcholine
by blocking the action of acetylcholinesterase, an enzyme that
catalyzes the hydrolysis (break down) of acetylcholine.
Galantamine Hydrobromide powder
An estimated four million Americans have Alzheimer's disease -- a
progressive loss of cognitive function so severe that it interferes with
an individual's ability to function. The number is expected to grow to
14 million by the middle of the next century. The disorder is the
third-most expensive illness in the United States, behind only heart
disease and cancer.
Reminyl was developed by the Janssen Research Foundation under a
co-development and licensing agreement with the UK-based Shire
Pharmaceuticals. The drug will be marketed by Janssen Pharmaceutica and
Ortho-McNeil Pharmaceutical in the United States.
Clinical Results
In trials ranging from 12 to 26 weeks, the effectiveness of Reminyl
was measured using two primary tools. Subjects' abilities in terms of
memory, orientation, reasoning and language were assessed using the
cognitive portion of the Alzheimer's Disease Assessment Scale
(ADAS-cog). Across all trials, results demonstrated that more subjects
taking Reminyl showed significant improvement in their cognitive
performance than subjects taking placebo.
The second primary measure of effectiveness was the Clinician's
Interview-Based Impression of Change plus Caregiver Information
(CIBIC-plus), which provides an overall assessment of patient
functioning - including behavior, organized thinking and activities of
daily living (such as dressing, eating and managing family finances).
The CIBIC-plus results from all trials also showed that the overall
scores for subjects taking Reminyl were statistically superior to
placebo.
The most frequent adverse events associated with the use of Reminyl
can be minimized by following the recommended dosage and administration.
Because this list is not all-inclusive, please consult a physician
to discuss any side effects and the individual appropriateness of the
drug.
Mechanism of Action
Galantamine, a tertiary alkaloid, is a competitive and reversible
inhibitor of acetylcholinesterase. While the precise mechanism of
galantamine's action is unknown, it may exert its therapeutic effect by
enhancing cholinergic function. This is accomplished by increasing the
concentration of acetylcholine through reversible inhibition of its
hydrolysis by cholinesterase. If this mechanism is correct,
galantamine's effect may lessen as the disease process advances and
fewer cholinergic neurons remain functionally intact. (from Reminyl
Prescribing Information).
In a small pilot study consume who consumed a natural dietary
supplement called nicotinomide riboside (NR) daily showed signs of
mimicking caloric restriction, which in mice has been linked to health
benefits.
Nicotinamide Riboside Chloride powder
Caloric restriction is a starvation diet. When lower level organisms
such as fruit flies, roundworms, rodents are raised on such a diet from
birth, slashing of caloric intake by about a third has health benefits
and, in some cases, extended lifespan. No humans have done that, it
would be a human rights violation to wean a baby on a starvation diet,
and claims about benefits in adults who took it up have too many
confounders to be anything more than anecdotes.
In a small pilot study, 12 lean and healthy men and women ages 55 to
79 from the Boulder area were given a placebo for six weeks, then took a
500 mg twice-daily dose of nicotinamide riboside chloride (NIAGEN).
Another 12 took nicotinamide riboside for the first six weeks, followed
by placebo. The researchers took blood samples and other physiological
measurements at the end of each treatment period. They found that the
supplement slightly improved blood pressure and arterial health,
particularly in those with mild hypertension but what they wanted to
find was that 1,000 mg daily of nicotinamide riboside boosted levels of
another compound called nicotinamide adenine dinucleotide (NAD+) by 60
percent. NAD+ is required for activation of enzymes called sirtuins,
which is hypothesized to be involved in the beneficial effects of
calorie restriction. It's involved in a host of metabolic actions
throughout the body, and tends to decline with age.
Some suggest that as an evolutionary survival mechanism, the body
conserves NAD+ when subjected to calorie restriction and that led to the
idea of supplementing with so-called "NAD+-precursors" like
nicotinamide riboside to promote healthier aging.
The pilot study also found that in 13 participants with elevated
blood pressure or stage 1 hypertension (120-139/80-89 mmHg), systolic
blood pressure was about 10 points lower after supplementation. A drop
of that magnitude could translate to a 25 percent reduction in heart
attack risk but this is a pilot study in healthy people, so it should
only be considered a viable technique if a company is willing to enter
it into clinical trials. Otherwise, it will remain just another
supplement for people who want to believe.