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How many times do you hear about it. Privacy sensitive information – sent by mobile phones – that is accessible to anyone on the street. Sometimes with nasty consequences and a rising discussing about online safety as a result. Sometimes you just have these calls that no-one is allowed to hear. Calls that aren’t coming from the anonymity. Besides a normal conversation, under four eyes with the addressed person, a VPN is the best option to send messages safely through the internet. A VPN service in combination with locking your messages should lead to full security. This locking of the messages is also called encryption.

Anonimity
Is your message encrypted, no one can then read your message. Your message is in anonymity. Interception of your message is possible, but opening your message is something totally different and so the content of the message can’t be found. The person who intercepted your message doesn’t have the key and can’t decipher your message. A key? Look at it als a password that can decipher the message. A message without a key or password is worth nothing. Because: not able to open, so not able to read. So very safe. Despite the fact that you can’t open the messages, you can trace the origin of the message, and also to who it is sent. This information can also be hidden by using a VPN service. Nothing to read and nothing to trace, there is not a safer way.

WhatsApp Encryption
Despite the fact that a lot of people don’t know what encrypting files really is, we work with it on a daily basis. Because almost everybody uses WhatsApp. This message service uses end-to-end encryption. All the messages are encrypted, without the need for the sender to do anything with it. When you sent a message with WhatsApp, the app will encrypt the message. The message then goes through the internet to the addressed person. The phone of the receiver has the key (or the password) automatically to open and read the sent messages. Both the sender as the receiver don’t have to do anything, it just happens. No matter the sensitivity of the information, no matter the importance of privacy: It is safe to send sensitive information through WhatsApp.


Dropbox
Still not fully sure about it? Almost anyone knows the cloud service Dropbox. In there, files – like for example photo’s – are stored. Dropbox encrypts just like WhatsApp the standard files you store. So even if curious hackers hack into this service, they can’t open and read the files you places in Dropbox.. Even the hackers miss the key to look at them. Incidentally, the encryption of services like WhatsApp are under pressure, mainly due to the fight against terrorism. For the AIVD, the encryption is a disaster. Messages from and to potential terrorist attacks can be intercepted but he content can’t be seen.VPN download
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Do you think you are safe online? In spite of your safety measures, hackers are capable of doing anything nowadays. The using of Spyware gives the hackers enough information to describe a person, even though they never met him. Sure, the safety technology may evolve, the hackers and their software will do the same. Curious in how you can tackle this? Let’s spy on them!

What is spyware and what does it do?
It’s some sort of malware that is installed on your computer without you knowing. Usually it is hidden and it collect information about your internet activity, the keylogging, passwords and other valuable data for incompetent persons. Spyware can also influence the computer action negatively, can steal password and other valuable data. Spyware can also install extra software, search your web browser or change the computer settings. Briefly, it compromises your safety and anonymity. Spyware can also be used as a type of adware, with which software will give unnecessary pop up ads. It is known that the makers of this software sometimes pay shareware developers to pair their spyware. This pairing happens with the legitimate software to install this at the unaware user.

We aren’t as well protected as you think
Anti-virus software and firewalls are targeted to secure your data on your computer. When you are connected with the internet, this software will do nothing to secure your data. If there is information to be found, it will sent this to a different computer. You can share information through a local private network, or Wifi or through your own internet provider. When you are connected to one of the connections, there can be a few try’s to collect and watch your data. To tackle this problem you have to make connection with a VPN service. A VPN service will make sure that your information can’t be traced or encrypted.

How does a VPN service protect against malware and virus?
VPN works in a very different way than antivirusforware of a firewall. Instead op collection viruses and malware on your device, it encrypts all your data and secures your data when they reach or leave your computer. When a user has access to a VPN network or when he opens a browser with VPN software the connection is fully secured. It doesn’t matter where you are or what type of device you are using. The full connection is secured. As a result, data exchange is secured and you can work safely and anonymously.

The protecting of your data
It doesn’t only stops the treat from viruses and malware that could potentially damage your hardware, it also stops the possibility for stealing your data which can lead to financial loss or even identity theft. A VPN or IP address is a software package that is the best on every single computer, telephone or tablet to build a safe and reliable connection between two contact points on the internet.
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The Internet: it is something without which we cannot live anymore, both as individual users and within companies. The Internet has made the world that we know smaller and yet, simultaneously, larger, exactly because of the innumerable possibilities it offers (on the private and on the business field).

This great expansion of the Internet provides, naturally, also for the existence of many more risks that come with it. Security and protection are often in short supply on the Internet and many people (or at least their surfing behavior) are tracked without their knowledge. At the same time, many people are aware of this and are looking for ways to once again ensure their online security and anonymity.

A VPN connection, or virtual private network, is the perfect solution for this: where a connection with the “regular” Internet can never fully guarantee the security of surfing data and personal information, this is very well the case with a VPN. With such a connection, there is always a mention of a so-called “tunnel” through which all online data is guided. The result? An Internet connection that is impossible to trace and which thus offers much more freedom for users.

Attain anonymity with a VPN
More and more people choose to set up a VPN connection instead of a simple Internet connection and this happens because such a connection makes you anonymous – so to speak – as an Internet user.

Nowadays, it is not difficult at all anymore to surf anonymously, surely due to the great offer of VPN services. Each Internet user possesses a certain IP address that gives information about the geographic location of this user. In this way, it can be determined which content (such as websites and online programs) can or cannot be viewed. For example, someone from the Netherlands may not be able to visit a Russian website because his or her IP address makes it impossible to do so.

A VPN connection, however, circumvents these geographic restrictions by giving the user a new IP address from a country of his choice. Services make it in this way possible to visit American online programs and websites, even if the user is located in the Netherlands. The result? Online anonymity and thus more freedom.


The importance of a no-log policy
There is of course always the risk with such a connection that third parties (such as the government or other official entities) retrieve information about which websites and programs you have visited or donwloaded as an Internet user. Even if your actual Internet behavior remains hidden, it is not impossible to know exactly where you are and what you do.

Many VPN services have, however, a solution for this: a no-log policy. This policy actually entails a simple guideline: all surfing data and history of Internet users (who are connected via the VPN server) are immediately removed so that nobody can learn what exactly this person has been doing. If a government authority requests data from the VPN provider about the browsing history of a given user, they will thus come back empty-handed: the provider itself does not possess this information to begin with.

The result of course is that you as a user of a VPN connection can always be sure of optimal online security and that third parties can never fine you for websites or programs that you have used in the past.


Why is a no-log policy so essential?
Online security is currently in short supply, that much is clear. VPN service offer Internet users the possibility to still enjoy privacy and protection against third parties by routing all Internet traffic via a closed virtual tunnel. In this way, browsing does not only become safer but also much more pleasant.

The no-log policy helps with this because all data about the Internet behavior of a user are removed. Whereas this information normally remains always available (and the risk of fines is thus also much higher), this policy ensures that you as a user of a VPN connection will never have to worry.
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In the modern jewelry world, industrial metals such as tungsten, titanium and stainless steel are in vogue, especially used in men’s jewelry, wedding bands and costume jewelry. Here are the benefits of tungsten:custom Tungsten Rings
Tungsten Affordability

Tungsten is a very affordable metal, and unlike the precious metals, is easy on your wallet. There are different grades of tungsten carbide used in jewelry which can impact the price. For example, high quality tungsten with carbon and nickel included can cost more than other lower grade tungsten carbide combinations.

Compare this white gold comfort fit wedding band with this comfort fit tungsten wedding band. The two rings are very similar looking but the difference in price is considerable!
Some people find that tungsten’s lack of monetary worth makes it cheap and therefore not a good choice for wedding bands. This comes down to personal preference and values.
Tungsten Durability

In the department of durability, tungsten carbide beats all other metals. This is how tungsten compares to other metals:

Gold (3 Mohs)
Platinum (4.5 Mohs)
Palladium (4.5 Mohs)
Rhodium (6 Mohs)
Titanium (6 Mohs)
Tungsten (9)
In fact, it is the hardest metal used in jewelry and the most scratch-resistant. As an object can only be scratched by another object that is harder than it, tungsten cannot be scratched by most materials. Some substances that can cause scratch tungsten are diamonds and moissanites. This means that regardless of the exposure your tungsten ring is subject to, it remains free of scratches.
Tungsten’s Luster

Tungsten rings are highly resistant to tarnishing and corrosion. Over time they do not change color or lose their shine.Because they don’t easily acquire scratches, tungsten remains lustrous and shiny. As a result, this metal has earned itself the nickname ‘forever polished’.
Tungsten is found in several popular colors. Gunmetal gray is a popular color for tungsten and makes for very handsome and unique wedding bands, while white offers a sleek and contemporary choice. White tungsten carbide is very similar in appearance to the popular platinum and white gold metals, giving a modern, stylish look to the wedding band.
You may be considering a black tungsten ring as this offers a striking and nonconventional look, ideal for someone looking to be different. However, black tungsten is made by plating the metal with a coating of black material. While plating tungsten allows for the metal to have different and attractive hues, it also means that over time the plate will flake off and require you to have the piece replated.
The jewelry market has a glittering future as the consumer appetite for jewelry related to the apparel and costume increased tremendously in recent years. In 2020, the jewelry industry is poised to cross $250 billion, which is almost 40 percent increase in sales compared to the last six to seven years.

According to experts, the growth in the sector can also be attributed to changes in the apparel, garments, and clothing industry where new trends have forced designers to continue innovation by offering matching jewelry designs.silver Tungsten Rings men

Factors of Change

In recent years, the pace of development is specifically attributed to the internationalization and consolidation of products, which has made it easier for new trends from around the world to proliferate the sector.

The growth of branded products is yet another reason for the development as brands are able to replicate and produce visionary designs that have attracted consumers who were not brand conscious. The reconfigured channels landscape, where online products have seen double-digit growth, is also boosting sales.

Similarly, hybrid consumption of jewelry has reduced the overall price increasing the buying power of consumers; whereas, fast-changing fashion trends have given impetus to price wars.
Jewelry and gemstone industry is still characterized by the dominance of local players and large national brands. This is evident by Christ in Germany and Chow Tai Fook in China, which are key players in their respective countries. However, these so-called local players are also consolidating their positions in the global market by integrating small local specialized chains. For instance, Tiffany & Co. and Cartier have made tremendous progress by buying shares of local companies or acquiring them outright.

Other well-known international brands such as Zara and H&M are also penetrating worldwide markets to capture sales channels. The pace of internationalization and consolidation will continue to grow in the coming years because this is an effective strategy that has also worked for related apparel and garments industry.

Already smaller players are feeling the heat as major brands are taking over Asian markets because large companies can easily get loans to expand their business, and they can access consumers through online channels. For instance, the share of large well-known Jewelry companies in India rose from a mere 5 percent to almost 35 percent in 2020, according to World Gold Council estimates.

Branded Jewelry

Branded jewelry is quickly becoming one of the most sought-after products in the market. According to McKinsey & Co. analysis, the share of branded jewelry was a mere 10 percent in 2003, which is expected to rise between 335 and 40 percent by 2020.

The newly acquired wealth in Asia has prompted consumers to acquire branded jewelry. Experts believe that a significant portion of consumers in the emerging markets are attracted to the brand because it shows their new wealth deposits. Apart from the “Show-off”, consumers in emerging markets are also interested in the brand because it generates trust and a sense of upgraded lifestyle. On the other hand, branded jewelry in North American and Europe owes its success to many young consumers who seek branded jewelry to enhance their sense of self-expression and self-realization.

In the past, brands such as Pandora and Tiffany & Co. made inroads into the jewelry sector; however, companies local brands such as Hermes and Dior are also taking charge due to the assortment of products and jewelry design. The trend indicates that consumers are also looking for new designs instead of just trusting the global brand.

For local artisans and jewelry makers, the impetus of branded jewelry is a bad omen because local artisans don’t have the muscles to challenge large companies. Still, savvy locals are partnering with companies such as Cadenza and Swarovski’s to showcase their designs. These companies offer curated multi-brand jewelry for their consumers making it a win-win situation for the consumer and the local artisans.

Reconfigured Sales Channels

New sales channels such as the Internet, mono-brand stores, and multi-brand boutique jewelry outlets are thriving in the face of the dynamic landscape. Online sales of jewelry segment will continue to increase in the coming years. The increase will be led by standardized affordable branded jewelry products because customers think that they understand the product without feeling it, which makes it easier to buy such products online.

Despite the emergence of online channels, most customers still prefer to feel the product by walking into a jewelry store because the sale of jewelry is a sensory experience. A lot of consumers also consult online stores and social media before purchasing the item from a brick-and-mortar store.

Monobrands stores such as Pandora have also gained market share as these stores rely on offering streamlined customer experience. Most customers will prefer mono-brand because it gives them a chance to get a more personalized experience and control over their buying patterns. Similarly, small multi-brand stores such as Cadenza and Swarovski’s are also providing a refined touch by concentrating on offering an assortment of unique jewelry from multiple brands.
From Stefanos Tsitsipas' dream day to Daniil Medvedev continuing his dominance by lifting his second ATP Masters 1000 title, relive the best moments of the 2019 Rolex Shanghai Masters.To get more shanghai masters, you can visit shine news official website.
1. Medvedev Prevails In Shanghai: Can anyone stop this man? The Russian outclassed Alexander Zverev to take the title in Shanghai without dropping a set. Medvedev is on a nine-match winning streak, all of which have come in straight sets, and he has prevailed in 29 of his past 32 matches. The 23-year-old also has more match wins (59) than anyone else on Tour this year.
2. Pavic/Soares Come Alive In Shanghai: Mate Pavic and Bruno Soares hadn't reached a final in the first seven tournaments of their new partnership, but they found their footing and defeated Lukasz Kubot/Marcelo Melo to prevail in Shanghai without dropping a set. It's the fourth Masters 1000 title for Soares and the first for Pavic.
3. Zverev Turns His Season Around: The German produced his best result of the year in Shanghai, defeating Roger Federer in the quarter-finals for his first Top 10 win of the season and then scoring a dominant semi-final victory over Berrettini. His week puts him in seventh place in the ATP Race to London as he looks to defend his title at the season-ending Nitto ATP Finals, held 10-17 November at The O2 in London.
4. Double The Fun: Stefanos Tsitsipas enjoyed one of the best days of his young career on Friday. The reigning Next Gen ATP Finals champion defeated Novak Djokovic in the quarter-finals for his first win over a current World No. 1., then learned he had qualified for his maiden appearance at the Nitto ATP Finals. The sixth seed in Shanghai advanced to the semi-finals before falling to eventual champion Medvedev.
5. Youth Movement: Djokovic and Federer were a combined 13-0 in Rolex Shanghai Masters quarter-finals before Friday, but that was before the ATP Tour's youth movement took over. Tsitsipas (d. Djokovic), Zverev (d. Federer) and Matteo Berrettini (d. Thiem) all scored big upsets, while Medvedev continued his run by defeating Fabio Fognini in the quarter-finals. It marked the first time time in 20 years that all four semi-finalists at a Masters 1000 event were under the age of 24.
6. London Calling: Kubot/Melo's quarter-final win in Shanghai over Ivan Dodig/Filip Polasek ensured they will return to the Nitto ATP Finals this year. Their season includes a title in Winston-Salem (d. Monroe/Sandgren) and runner-up showings at four events, including Shanghai (l. to Pavic/Soares) and the BNP Paribas Open (l. to Mektic/Zeballos).
7. Pretty Please, Son: Federer's parents are not a regular fixture at his matches, but Robert and Lynette Federer both accompanied him to Shanghai this year. It was Lynette's third trip to the city, but Robert's first, and he was so enamoured that he already wants his son to put the eighth Masters 1000 event of the year on his schedule for 2020.
8. Rivalry Bingo: Dominic Thiem and Pablo Carreno Busta squared off for the first time at an ITF Futures event in Morocco in 2012. Their rivalry quickly progressed to the ATP Challenger Tour the following year and reached the ATP Tour in 2015 with a showdown in Gstaad. The Austrian won their latest battle in Shanghai to take a 6-0 lead in their FedEx ATP Head2Head rivalry, but it likely won't be the last time they meet.
9. On Top Of The World: Juan Sebastian Cabal and Robert Farah clinched the year-end No. 1 ATP Doubles Team Ranking for the first time as a result of their second-round win over John Isner and Sam Querrey. They became the second all-South American doubles team to accomplish the feat since the ATP Doubles Team Rankings began in 1984. Cabal/Farah have won five-tour level titles this year, including their first two Grand Slam titles Wimbledon (d. Mahut/Roger-Vasselin) and the US Open (d. Mektic/Zeballos).
10. Roger Returns, On Twitter: By his own admission, Federer is not the most prolific tweeter and will take breaks from social media for months at a time. But the Swiss brushed off his Twitter account to answer fan questions and even ask for recommendations on what to see in Shanghai. With his next two tournaments coming up this month in Basel and Paris, its shouldn’t be long before we see Federer back on social media again.
The NBA regular season is upon us. After a long, incredibly busy summer, the games begin again on Tuesday night – most notably with the Toronto Raptors raising their first-ever championship banner before taking on the New Orleans Pelicans at Scotiabank Arena.To get more nba as, you can visit shine news official website.

But despite the Raptors’ defending-champion status, they certainly don’t feel like big favourites to repeat.One obvious reason for this is the departure of 2019 Finals MVP Kawhi Leonard, but another major factor is the insane amount of parity across the NBA this season.

For the first time in seemingly forever there’s no clear-cut favourite to win it all. Instead, there’s a large swath of good-to-very good teams that look like they have a legitimate shot or are, perhaps, just one piece or one big break short of one.

As such, this season we’re going to tackle the power rankings a little differently than in years past. Instead of ranking each team 1-30, we’re going to divvy up groups of teams into tiers.So, before the ball tips and things get going for real, here’s the first edition of the NBA Tier List.Due to a mixture of raw star power, depth and experience, these five clubs are the cream of the crop heading into the season.

Star capital is apparent across the board here, with players like LeBron James, Anthony Davis, Kawhi Leonard and Paul George on the Los Angeles Lakers and Clippers, respectively, in addition to reigning league MVP Giannis Antetokounmpo on the Milwaukee Bucks, and Joel Embiid and Ben Simmons on the Philadelphia 76ers.

The Denver Nuggets’ wattage isn’t as obvious, but Nikola Jokic was, and should still remain, an MVP candidate, while Canadian Jamal Murray could take the next step and become an all-star this season.

All of these teams are expected to compete for the top spots of their respective conferences on the strength of their top-end talent, but they all also feature a fair amount of depth in terms of role players and specialists who can help them get over the top.

As mentioned before, there’s a lot of parity around the league this season, but for the time being these fives team like the far-too-early championship favourites.This is what was meant by a ton of good-to-very good teams.

These eight clubs could easily leap into the group above if things break right. But the reason they’re not there now is because they each come with key questions that could hold them back.

For example, there’s little denying the Raptors’ depth, but without Leonard — one of the three best players in the league — how legitimate are their championship aspirations even if Pascal Siakam takes another step forward?

Or in the case of the Golden State Warriors and Houston Rockets, their top talent is literally MVP calibre, but what about their overall depth? And for teams like the Utah Jazz or Brooklyn Nets, while it’s true adding players like Mike Conley and Kyrie Irving is a big boost, the jury is still out on whether it’ll be enough.All of these teams have questions that need to be answered before they can make a leap into the top tier.None of these 10 clubs are outright bad, per se, but it’s hard to see them pushing for anything beyond the final three playoff spots in their respective conferences.

The Sacramento Kings are a perfect example of this. They’re a team with depth and talent — see players like De’Aaron Fox and Buddy Hield — and look primed to make a leap back to relevancy. Unfortunately for them, the West is so deep that relevancy likely means scratching for a No. 7 or 8 seed.

And looking at an Eastern Conference example, the Orlando Magic are a well-coached team with intriguing talent that should only grow after a respectable five-game playoff exit to the Raptors. But what is the Magic’s realistic ceiling here? Can Nikola Vucevic make yet another leap and turn this Orlando side from a No. 6 seed into a top-three seed in the East?

All of these squads have talent. The problem is they either don’t have enough of it or they’re simply going to get gate-kept by clubs within the higher tiers.
Hydrochlorothiazide - Clinical Pharmacology

The mechanism of the antihypertensive effect of thiazides is unknown. Hydrochlorothiazide powder does not usually affect normal blood pressure.

Hydrochlorothiazide affects the distal renal tubular mechanism of electrolyte reabsorption. At maximal therapeutic dosage all thiazides are approximately equal in their diuretic efficacy.Hydrochlorothiazide increases excretion of sodium and chloride in approximately equivalent amounts. Natriuresis may be accompanied by some loss of potassium and bicarbonate.After oral use diuresis begins within 2 hours, peaks in about 4 hours and lasts about 6 to 12 hours.

Pharmacokinetics and Metabolism

Hydrochlorothiazide is not metabolized but is eliminated rapidly by the kidney. When plasma levels have been followed for at least 24 hours, the plasma half-life has been observed to vary between 5.6 and 14.8 hours. At least 61 percent of the oral dose is eliminated unchanged within 24 hours. Hydrochlorothiazide crosses the placental but not the blood-brain barrier and is excreted in breast milk.

Indications and Usage for Hydrochlorothiazide

Hydrochlorothiazide tablets, USP are indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy.Hydrochlorothiazide tablets, USP have also been found useful in edema due to various forms of renal dysfunction such as nephrotic syndrome, acute glomerulonephritis, and chronic renal failure.

Hydrochlorothiazide tablets, USP are indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension.

Use in Pregnancy

Routine use of diuretics during normal pregnancy is inappropriate and exposes mother and fetus to unnecessary hazard. Diuretics do not prevent development of toxemia of pregnancy and there is no satisfactory evidence that they are useful in the treatment of toxemia.

Edema during pregnancy may arise from pathologic causes or from the physiologic and mechanical consequences of pregnancy. Thiazides are indicated in pregnancy when edema is due to pathologic causes, just as they are in the absence of pregnancy (see PRECAUTIONS, Pregnancy). Dependent edema in pregnan­cy, resulting from restriction of venous return by the gravid uterus, is properly treated through elevation of the lower extremities and use of support stockings. Use of diuretics to lower intravascular volume in this instance is illogical and unneces­sary. During normal pregnancy there is hypervolemia which is not harmful to the fetus or the mother in the absence of cardiovascular disease. However, it may be associated with edema, rarely generalized edema. If such edema causes discomfort, in­creased recumbency will often provide relief. Rarely this edema may cause extreme discomfort which is not relieved by rest. In these instances, a short course of diuretic therapy may provide relief and be appropriate.
Investigations into the mode of action of furosemide have utilized micropuncture studies is rats, stop flow experiments in dogs and various clearance studies in both humans and experimental animals. It has been demonstrated that furosemide inhibits primarily the reabsorption of sodium and chloride not only in the proximal and distal tubules but also in the loop of Henle. The high degree of efficacy is largely due to this unique site of action. The action on the distal tubule is independent of any inhibitory effect on carbonic anhydrase and aldosterone.Furosemide powder

Recent evidence suggests that furosemide glucuronide is the only or at least the major biotransformation product of furosemide in man. Furosemide is extensively bound to plasma proteins, mainly to albumin. Plasma concentrations ranging from 1 to 400 μg/mL are 91 to 99% bound in healthy individuals. The unbound fraction averages 2.3 to 4.1% at therapeutic concentrations.

The onset of diuresis following intravenous administration is within 5 minutes and somewhat later after intramuscular administration. The peak effect occurs within the first half hour. The duration of diuretic effect is approximately 2 hours.

In fasted normal men, the mean bioavailability of furosemide from furosemide tablets and furosemide oral solution is 64 % and 60%, respectively, of that from an intravenous injection of the drug. Although furosemide is more rapidly absorbed from the oral solution (50 minutes) than from the tablet (87 minutes), peak plasma levels and area under the plasma concentration-time curves do not differ significantly. Peak plasma concentrations increase with increasing dose but times-to-peak do not differ among doses. The terminal half-life of furosemide is approximately 2 hours.

Significantly more furosemide is excreted in urine following the intravenous injection than after the tablet or oral solution. There are no significant differences between the two oral formulations in the amount of unchanged drug excreted in urine.

Geriatric Population

Furosemide binding to albumin may be reduced in elderly patients. Furosemide is predominantly excreted unchanged in the urine. The renal clearance of furosemide after intravenous administration in older healthy male subjects (60-70 years of age) is statistically significantly smaller than in younger healthy male subjects (20-35 years of age). The intial diuretic effect of furosemide in older subjects is decreased relative to younger subjects. (See PRECAUTIONS: Geriatric Use.)
Parenteral therapy should be reserved for patients unable to take oral medication or for patients in emergency clinical situations.

Edema: Furosemide is indicated in adults and pediatric patients for the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Furosemide is particularly useful when an agent with greater diuretic potential is desired.

Furosemide is indicated as adjunctive therapy in acute pulmonary edema. The intravenous administration of furosemide is indicated when a rapid onset of diuresis is desired, e.g., in acute pulmonary edema.

If gastrointestinal absorption is impaired or oral medication is not practical for any reason, furosemide is indicated by the intravenous or intramuscular route. Parenteral use should be replaced with oral furosemide as soon as practical
Budesonide and formoterol (eformoterol) fumarate dihydrate powder for inhalation



This leaflet answers some common questions about DuoResp Spiromax. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist.Formoterol
All medicines have benefits and risks. Your doctor has weighed the risks of you using DuoResp Spiromax against the benefits they expect it will have for you.DuoResp Spiromax is inhaled into the lungs for the treatment of asthma or Chronic Obstructive Pulmonary Disease (COPD).
DuoResp Spiromax contains two active ingredients in one inhaler: budesonide and formoterol (eformoterol) fumarate dihydrate (hereafter referred to as formoterol).
Budesonide belongs to a group of medicines called corticosteroids. Budesonide acts directly on your airways to reduce inflammation.
Formoterol belongs to a group of medicines called beta-2-agonists. Formoterol opens up the airways to help you breathe more easily.
ASTHMA

Asthma is a disease where the airways of the lungs become narrow and inflamed (swollen), making it difficult to breathe. This may be due to an allergy to house dust mites, smoke, air pollution or other things that irritate your lungs.
DuoResp Spiromax contains budesonide and formoterol in one inhaler.
Budesonide helps to improve your condition and to prevent asthma attacks from occurring. It is a "preventer" and needs to be taken regularly.
Formoterol helps you breathe more easily. It should also be taken regularly to help control your symptoms.
Budesonide and formoterol in combination, when used regularly, will help prevent asthma attacks and make it easier to breathe normally.
DuoResp Spiromax can also be used as a "reliever" when needed to treat your symptoms when your asthma gets worse and when used regularly will help prevent asthma attacks.COPD (which includes chronic bronchitis and emphysema) is a long-term lung disease. There is often permanent narrowing and persistent inflammation of the airways.
Symptoms may include difficulty in breathing (breathlessness or wheezing), coughing and increased sputum.
When used as prescribed, DuoResp Spiromax will help to control your COPD symptoms (i.e. breathing difficulties)
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